Check the conditions that apply to you before taking this
medication:
["Before using aspirin, caffeine, and dihydrocodeine", "In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do
This is a decision you and your doctor will make
For this medicine, the following should be considered:", "Allergies", "Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines
Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals
For non-prescription products, read the label or package ingredients carefully.", "Pediatric", "Use of aspirin, caffeine, and dihydrocodeine combination is not recommended in children 12 years of age or younger. ", "Synalgos\\\\u00ae-DC should not be used to relieve pain after surgery removal of tonsils or adenoids in children
Severe breathing problems and deaths have been reported in some children who received codeine after tonsil or adenoid surgery. ", "Geriatric", "Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aspirin, caffeine, and dihydrocodeine combination in the elderly
However, elderly patients are more likely to have age-related lung, liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving aspirin, caffeine, and dihydrocodeine combination in order to avoid potentially serious side effects. ", "\\\\n\\\\n", "Breast Feeding", "Studies in women breastfeeding have demonstrated harmful infant effects
An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.", "Interactions with Medicines", "Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur
In these cases, your doctor may want to change the dose, or other precautions may be necessary
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.", "Using this medicine with any of the following medicines is not recommended
Your doctor may decide not to treat you with this medication or change some of the other medicines you take.", "Abrocitinib\\\\nDefibrotide\\\\nDichlorphenamide\\\\nInfluenza Virus Vaccine, Live\\\\nKetorolac\\\\nNalmefene\\\\nNaltrexone\\\\nRiociguat\\\\nSafinamide\\\\nSamidorphan\\\\nViloxazine", "Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.", "Abiraterone Acetate\\\\nAcarbose\\\\nAceclofenac\\\\nAcemetacin\\\\nAcenocoumarol\\\\nAcepromazine\\\\nAcetazolamide\\\\nAlclometasone\\\\nAldosterone\\\\nAlfentanil\\\\nAlipogene Tiparvovec\\\\nAlmotriptan\\\\nAlprazolam\\\\nAlteplase, Recombinant\\\\nAmcinonide\\\\nAmifampridine\\\\nAmikacin\\\\nAmiloride\\\\nAmineptine\\\\nAmiodarone\\\\nAmitriptyline\\\\nAmitriptylinoxide\\\\nAmobarbital\\\\nAmoxapine\\\\nAmphetamine\\\\nAmphotericin B\\\\nAmprenavir\\\\nAmtolmetin Guacil\\\\nAnagrelide\\\\nAnileridine\\\\nAnisindione\\\\nApixaban\\\\nAprepitant\\\\nArdeparin\\\\nArgatroban\\\\nAripiprazole\\\\nArmodafinil\\\\nAsenapine\\\\nAtazanavir\\\\nBacitracin\\\\nBaclofen\\\\nBeclomethasone\\\\nBemetizide\\\\nBemiparin\\\\nBenazepril\\\\nBendroflumethiazide\\\\nBenperidol\\\\nBenzhydrocodone\\\\nBenzphetamine\\\\nBenzthiazide\\\\nBetamethasone\\\\nBetrixaban\\\\nBivalirudin\\\\nBoceprevir\\\\nBosentan\\\\nBrinzolamide\\\\nBromazepam\\\\nBromfenac\\\\nBromopride\\\\nBrompheniramine\\\\nBudesonide\\\\nBufexamac\\\\nBumetanide\\\\nBupropion\\\\nBuspirone\\\\nButabarbital\\\\nCalcium Oxybate\\\\nCannabidiol\\\\nCannabis\\\\nCaplacizumab-yhdp\\\\nCapmatinib\\\\nCapreomycin\\\\nCaptopril\\\\nCarbamazepine\\\\nCarbinoxamine\\\\nCarisoprodol\\\\nCarphenazine\\\\nCelecoxib\\\\nCertoparin\\\\nCetirizine\\\\nChloral Hydrate\\\\nChlordiazepoxide\\\\nChlorothiazide\\\\nChlorpheniramine\\\\nChlorpromazine\\\\nChlorpropamide\\\\nChlorthalidone\\\\nChlorzoxazone\\\\nCholine Salicylate\\\\nCiclesonide\\\\nCilostazol\\\\nCimetidine\\\\nCinacalcet\\\\nCiprofloxacin\\\\nCisplatin\\\\nCitalopram\\\\nClarithromycin\\\\nClobazam\\\\nClobetasol\\\\nClobetasone\\\\nClocortolone\\\\nClomipramine\\\\nClonazepam\\\\nClonixin\\\\nClopamide\\\\nClopidogrel\\\\nClorazepate\\\\nClozapine\\\\nCobicistat\\\\nCocaine\\\\nCodeine\\\\nConivaptan\\\\nCortisone\\\\nCrizotinib\\\\nCurcumin\\\\nCyclobenzaprine\\\\nCyclopenthiazide\\\\nCyclosporine\\\\nCyclothiazide\\\\nDabigatran Etexilate\\\\nDalteparin\\\\nDanaparoid\\\\nDaridorexant\\\\nDarunavir\\\\nDeflazacort\\\\nDelavirdine\\\\nDesipramine\\\\nDesirudin\\\\nDesmopressin\\\\nDesonide\\\\nDesoximetasone\\\\nDesvenlafaxine\\\\nDexamethasone\\\\nDexibuprofen\\\\nDexketoprofen\\\\nDexmedetomidine\\\\nDextroamphetamine\\\\nDextromethorphan\\\\nDiazepam\\\\nDiazoxide\\\\nDibenzepin\\\\nDichloralphenazone\\\\nDiclofenac\\\\nDicumarol\\\\nDifenoxin\\\\nDiflorasone\\\\nDiflucortolone\\\\nDiflunisal\\\\nDifluprednate\\\\nDigoxin\\\\nDiltiazem\\\\nDiphenhydramine\\\\nDiphenoxylate\\\\nDipyrone\\\\nDolasetron\\\\nDonepezil\\\\nDorzolamide\\\\nDothiepin\\\\nDoxepin\\\\nDoxylamine\\\\nDronedarone\\\\nDroperidol\\\\nDroxicam\\\\nDuloxetine\\\\nEdoxaban\\\\nEfavirenz\\\\nEletriptan\\\\nEmtricitabine\\\\nEnalapril\\\\nEnalaprilat\\\\nEnflurane\\\\nEnoxaparin\\\\nEnzalutamide\\\\nEplerenone\\\\nEptifibatide\\\\nErythromycin\\\\nEscitalopram\\\\nEsketamine\\\\nEslicarbazepine Acetate\\\\nEstazolam\\\\nEszopiclone\\\\nEthacrynic Acid\\\\nEthchlorvynol\\\\nEthopropazine\\\\nEthylmorphine\\\\nEtodolac\\\\nEtofenamate\\\\nEtoricoxib\\\\nEtozolin\\\\nEtravirine\\\\nFelbinac\\\\nFenfluramine\\\\nFenoprofen\\\\nFentanyl\\\\nFepradinol\\\\nFeprazone\\\\nFeverfew\\\\nFlibanserin\\\\nFloctafenine\\\\nFlucloronide\\\\nFluconazole\\\\nFludrocortisone\\\\nFlufenamic Acid\\\\nFlumethasone\\\\nFlunisolide\\\\nFluocinolone\\\\nFluocinonide\\\\nFluocortin\\\\nFluocortolone\\\\nFluorometholone\\\\nFluoxetine\\\\nFluphenazine\\\\nFlurandrenolide\\\\nFlurazepam\\\\nFlurbiprofen\\\\nFluspirilene\\\\nFluticasone\\\\nFluvoxamine\\\\nFondaparinux\\\\nFosamprenavir\\\\nFosaprepitant\\\\nFoscarnet\\\\nFosinopril\\\\nFosphenytoin\\\\nFospropofol\\\\nFrovatriptan\\\\nFurazolidone\\\\nFurosemide\\\\nGabapentin\\\\nGabapentin Enacarbil\\\\nGentamicin\\\\nGepirone\\\\nGinkgo\\\\nGivosiran\\\\nGlimepiride\\\\nGlipizide\\\\nGlyburide\\\\nGossypol\\\\nGranisetron\\\\nHalazepam\\\\nHalcinonide\\\\nHalobetasol\\\\nHaloperidol\\\\nHalothane\\\\nHeparin\\\\nHexobarbital\\\\nHydrochlorothiazide\\\\nHydrocodone\\\\nHydrocortisone\\\\nHydroflumethiazide\\\\nHydromorphone\\\\nHydroxytryptophan\\\\nHydroxyzine\\\\nIbrutinib\\\\nIbuprofen\\\\nIdelalisib\\\\nImatinib\\\\nImipramine\\\\nIndapamide\\\\nIndinavir\\\\nIndomethacin\\\\nInotersen\\\\nIobenguane I 131\\\\nIproniazid\\\\nIsocarboxazid\\\\nIsoflurane\\\\nItraconazole\\\\nIvacaftor\\\\nKanamycin\\\\nKetamine\\\\nKetazolam\\\\nKetobemidone\\\\nKetoconazole\\\\nKetoprofen\\\\nLacosamide\\\\nLasmiditan\\\\nLemborexant\\\\nLepirudin\\\\nLevocetirizine\\\\nLevomilnacipran\\\\nLevorphanol\\\\nLinezolid\\\\nLisdexamfetamine\\\\nLisinopril\\\\nLithium\\\\nLofepramine\\\\nLofexidine\\\\nLomitapide\\\\nLopinavir\\\\nLorazepam\\\\nLorcaserin\\\\nLornoxicam\\\\nLoteprednol\\\\nLoxapine\\\\nLoxoprofen\\\\nLumacaftor\\\\nLumiracoxib\\\\nMacimorelin\\\\nMagnesium Oxybate\\\\nMeclizine\\\\nMeclofenamate\\\\nMedrysone\\\\nMefenamic Acid\\\\nMelitracen\\\\nMeloxicam\\\\nMelperone\\\\nMelphalan\\\\nMeperidine\\\\nMephobarbital\\\\nMeprobamate\\\\nMesoridazine\\\\nMetaxalone\\\\nMetformin\\\\nMethadone\\\\nMethamphetamine\\\\nMethazolamide\\\\nMethdilazine\\\\nMethocarbamol\\\\nMethohexital\\\\nMethotrexate\\\\nMethotrimeprazine\\\\nMethyclothiazide\\\\nMethylene Blue\\\\nMethylprednisolone\\\\nMetoclopramide\\\\nMetolazone\\\\nMibefradil\\\\nMidazolam\\\\nMifepristone\\\\nMilnacipran\\\\nMirabegron\\\\nMirtazapine\\\\nMitotane\\\\nMoclobemide\\\\nModafinil\\\\nMoexipril\\\\nMolindone\\\\nMometasone\\\\nMoricizine\\\\nMorniflumate\\\\nMorphine\\\\nMorphine Sulfate Liposome\\\\nNabumetone\\\\nNadroparin\\\\nNafcillin\\\\nNaproxen\\\\nNaratriptan\\\\nNateglinide\\\\nNefazodone\\\\nNelfinavir\\\\nNeomycin\\\\nNepafenac\\\\nNetilmicin\\\\nNevirapine\\\\nNialamide\\\\nNicomorphine\\\\nNicorandil\\\\nNiflumic Acid\\\\nNilotinib\\\\nNimesulide\\\\nNimesulide Beta Cyclodextrin\\\\nNitrazepam\\\\nNitrous Oxide\\\\nNortriptyline\\\\nOlanzapine\\\\nOndansetron\\\\nOpipramol\\\\nOpium\\\\nOpium Alkaloids\\\\nOrphenadrine\\\\nOxaprozin\\\\nOxazepam\\\\nOxcarbazepine\\\\nOxycodone\\\\nOxymorphone\\\\nOxyphenbutazone\\\\nOzanimod\\\\nPalbociclib\\\\nPalonosetron\\\\nPapaveretum\\\\nParamethasone\\\\nParecoxib\\\\nParegoric\\\\nParnaparin\\\\nParomomycin\\\\nParoxetine\\\\nPeginterferon Alfa-2b\\\\nPemetrexed\\\\nPentobarbital\\\\nPentosan Polysulfate Sodium\\\\nPentoxifylline\\\\nPerampanel\\\\nPerazine\\\\nPericiazine\\\\nPerindopril\\\\nPerphenazine\\\\nPhenelzine\\\\nPhenindione\\\\nPhenobarbital\\\\nPhenprocoumon\\\\nPhenylbutazone\\\\nPhenytoin\\\\nPiketoprofen\\\\nPimozide\\\\nPiperacetazine\\\\nPipotiazine\\\\nPiracetam\\\\nPiretanide\\\\nPiritramide\\\\nPiroxicam\\\\nPixantrone\\\\nPlazomicin\\\\nPolythiazide\\\\nPosaconazole\\\\nPotassium Citrate\\\\nPotassium Oxybate\\\\nPranoprofen\\\\nPrasugrel\\\\nPrazepam\\\\nPrednicarbate\\\\nPrednisolone\\\\nPrednisone\\\\nPregabalin\\\\nPrimidone\\\\nProcarbazine\\\\nProchlorperazine\\\\nProglumetacin\\\\nPromazine\\\\nPromethazine\\\\nPropofol\\\\nPropyphenazone\\\\nProquazone\\\\nProtein C\\\\nProtriptyline\\\\nQuazepam\\\\nQuetiapine\\\\nQuinapril\\\\nQuinethazone\\\\nQuinidine\\\\nQuinine\\\\nRamelteon\\\\nRamipril\\\\nRanitidine\\\\nRanolazine\\\\nRasagiline\\\\nRemifentanil\\\\nRemimazolam\\\\nRemoxipride\\\\nRepaglinide\\\\nReteplase, Recombinant\\\\nReviparin\\\\nRifabutin\\\\nRifampin\\\\nRifapentine\\\\nRimexolone\\\\nRitlecitinib\\\\nRitonavir\\\\nRivaroxaban\\\\nRizatriptan\\\\nRofecoxib\\\\nRolapitant\\\\nRopeginterferon Alfa-2b-njft\\\\nSalicylic Acid\\\\nSalsalate\\\\nSaquinavir\\\\nScopolamine\\\\nSecobarbital\\\\nSelegiline\\\\nSelumetinib\\\\nSertindole\\\\nSertraline\\\\nSibutramine\\\\nSildenafil\\\\nSodium Oxybate\\\\nSodium Salicylate\\\\nSpectinomycin\\\\nSpirapril\\\\nSpironolactone\\\\nSt John's Wort\\\\nStreptomycin\\\\nSufentanil\\\\nSulindac\\\\nSulodexide\\\\nSulpiride\\\\nSumatriptan\\\\nSuvorexant\\\\nTacrolimus\\\\nTapentadol\\\\nTelaprevir\\\\nTelithromycin\\\\nTemazepam\\\\nTenofovir Alafenamide\\\\nTenofovir Disoproxil Fumarate\\\\nTenoxicam\\\\nTerbinafine\\\\nThiethylperazine\\\\nThiopental\\\\nThiopropazate\\\\nThioridazine\\\\nThiothixene\\\\nTianeptine\\\\nTiaprofenic Acid\\\\nTicagrelor\\\\nTiclopidine\\\\nTilidine\\\\nTinzaparin\\\\nTirofiban\\\\nTizanidine\\\\nTobramycin\\\\nTocilizumab\\\\nTolazamide\\\\nTolbutamide\\\\nTolfenamic Acid\\\\nTolmetin\\\\nTolonium Chloride\\\\nTopiramate\\\\nTorsemide\\\\nTramadol\\\\nTrandolapril\\\\nTranylcypromine\\\\nTrazodone\\\\nTreprostinil\\\\nTriamcinolone\\\\nTriamterene\\\\nTriazolam\\\\nTrichlormethiazide\\\\nTrifluoperazine\\\\nTrifluperidol\\\\nTriflupromazine\\\\nTrimeprazine\\\\nTrimipramine\\\\nTryptophan\\\\nTurmeric\\\\nValdecoxib\\\\nValproic Acid\\\\nVancomycin\\\\nVaricella Virus Vaccine, Live\\\\nVenlafaxine\\\\nVerapamil\\\\nVilazodone\\\\nVoriconazole\\\\nVortioxetine\\\\nWarfarin\\\\nXipamide\\\\nZaleplon\\\\nZiprasidone\\\\nZolmitriptan\\\\nZolpidem\\\\nZopiclone\\\\nZotepine\\\\nZuranolone", "\\\\n\\\\n", "Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.", "Acebutolol\\\\nAtenolol\\\\nBetaxolol\\\\nBisoprolol\\\\nCarteolol\\\\nCarvedilol\\\\nCeliprolol\\\\nDelapril\\\\nEsmolol\\\\nImidapril\\\\nLabetalol\\\\nLevobunolol\\\\nMetipranolol\\\\nMetoprolol\\\\nNadolol\\\\nNebivolol\\\\nNitroglycerin\\\\nOxprenolol\\\\nPenbutolol\\\\nPindolol\\\\nProbenecid\\\\nPropranolol\\\\nSotalol\\\\nStreptokinase\\\\nTamarind\\\\nTemocapril\\\\nTenecteplase\\\\nTimolol", "Interactions with Food/Tobacco/Alcohol", "Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur
Using alcohol or tobacco with certain medicines may also cause interactions to occur
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.", "Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.", "Ethanol\\\\nGrapefruit Juice\\\\nTobacco", "Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.", "Ethanol", "Other Medical Problems", "The presence of other medical problems may affect the use of this medicine
Make sure you tell your doctor if you have any other medical problems, especially:", "Addison's disease (adrenal gland problem) or\\\\nAlcohol abuse, or history of or\\\\nBrain , tumor, history of or\\\\nBreathing or lung problems (eg, COPD, sleep apnea, respiratory depression) or\\\\nCor pulmonale (serious heart condition) or\\\\nDepression, history of or\\\\nDrug dependence, especially with narcotic abuse or dependence, or history of or\\\\nHead injuries, history of or\\\\nHyperkalemia (high potassium levels in the blood) or\\\\nIncreased pressure in the head or\\\\nMental health problems, history of or\\\\nObesity (overweight) or\\\\nWeakened physical condition\\\\u2014Use with caution
May increase risk for more serious side effects. ", "\\\\n\\\\n", "Bleeding problems or\\\\nHypotension (low blood pressure) or\\\\nPancreatitis swelling of the pancreas) or\\\\nStomach or bowel problems (eg, peptic ulcer disease, bleeding), active or history of or\\\\nSeizures, history of\\\\u2014Use with caution
May make these conditions worse. ", "Dehydration or\\\\nHypovolemia\\\\u2014Must be corrected first before using this medicine. ", "Hemophilia (bleeding problem) or\\\\nReye's syndrome or\\\\nSevere asthma, asthma with nasal polyps and runny nose, trouble breathing, or other lung problems or\\\\nStomach or bowel blockage (including paralytic ileus) or\\\\nSurgery (eg, nasopharyngeal tonsils, tonsils)\\\\u2014Should not be used in patients with these conditions. ", "Kidney disease or\\\\nLiver disease\\\\u2014Use with caution
The effects may be increased because of slower removal of the medicine from the body. ", "\\\\nRelated/similar drugs\\\\nacetaminophen, cyclobenzaprine, tramadol, naproxen, oxycodone, Tylenol\\\\n"]
Talk to your doctor
One or more conditions apply to you. Please
consult a healthcare professional before taking this medication.